A new article has been published in Blood from a collaborative project between Sophie Kellaway and the Heidenreich lab based at the Princess Maxima Centre in the Netherlands.
In this study, we showed that functionalised lipid nanoparticle targeting of RUNX1::RUNX1T1 in primary patient AML cells induces a bidirectional differentiation, depleting the leukaemia stem cells.
You can read the full study here: https://ashpublications.org/blood/article/146/24/2963/547449/Fusion-gene-depletion-eliminates-stemness-and
Commentary here: https://ashpublications.org/blood/article/146/24/2857/556826/Defusing-AML-targeting-t-8-21-forces-myeloid